Some of the factors that might cause a spleen to enlarge include:
- Viral, fungal, and bacterial infections.
- Hemolytic anemia, in which the spleen destroys healthy red blood cells.
- Blood clots of the veins from the spleen or liver.
- Liver diseases like cirrhosis.
- Cancers, such as leukemia and lymphoma.
- Metabolic diseases.
- Sarcoidosis.
- Amyloidosis.
- Felty syndrome.
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